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This review summarizes results from studies of humans, preclinical animal models, and cultured endothelial cells that document toxicities of cigarette smoke exposure on pulmonary endothelial cell functions, including barrier dysfunction, endothelial activation and inflammation, apoptosis, and vasoactive mediator production

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Researchers found that alcohol and tobacco use combined cost more than a quarter of a billion disability-adjusted life-years worldwide, while illegal drugs only accounted for tens of millions in comparison

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